proprotein convertase 1 การใช้

Proprotein convertase 1 is the enzyme largely responsible for the first step in the biosynthesis of insulin.
Following the action of proprotein convertase 1, a carboxypeptidase is required to remove the basic residues from the processing intermediate and generate the bioactive form of insulin.
There are nine subtilisin homologs in mammals; in addition to proprotein convertase 1 and 2, other members of this enzyme family include furin, SKI1 / S1P.
The mice or humans, most likely due to the presence of the second convertase, although mice lacking proprotein convertase 1 activity show a number of defects including slow growth.
Proprotein convertase 1 is a calcium ( Ca 2 + ) activated serine endoprotease ( meaning that a serine residue is part of the active site that hydrolyzes the peptide bond within the substrate ).